Motif ID: HOX{A5,B5}.p2

Z-value: 1.064


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
Hoxa5 15402 homeobox A5
Hoxb5 15413 homeobox B5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hoxa5chr6_-_52154325-0.464.1e-11Click!
Hoxb5chr11_+_96164825-0.343.4e-06Click!


Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_57226987 40.194 NM_009451
Tubb4
tubulin, beta 4
chr8_-_73011217 15.258 NM_182991
Tmem59l
transmembrane protein 59-like
chr9_-_35365985 13.779 NM_013932
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr11_+_56825307 13.775 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chrX_+_133357268 13.554 NM_011123
Plp1
proteolipid protein (myelin) 1
chr13_+_54472806 13.406 Cplx2
complexin 2
chr11_+_56825258 13.205 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr12_-_80084464 12.098 NM_001170401
Tmem229b
transmembrane protein 229B
chr10_-_80477630 11.739 NM_010319
Gng7
guanine nucleotide binding protein (G protein), gamma 7
chr11_+_56825192 11.736 NM_001113325
NM_008165
Gria1

glutamate receptor, ionotropic, AMPA1 (alpha 1)

chr6_+_145070255 11.727 NM_008511
Lrmp
lymphoid-restricted membrane protein
chr2_+_177876635 11.192 NM_028806
Phactr3
phosphatase and actin regulator 3
chr12_-_36768992 10.867 Tspan13
tetraspanin 13
chr5_-_143084635 10.069 Mmd2
monocyte to macrophage differentiation-associated 2
chr5_-_143084677 9.839 NM_175217
Mmd2
monocyte to macrophage differentiation-associated 2
chr19_-_45890238 9.810 NM_030716
NM_145703
NM_145704
Kcnip2


Kv channel-interacting protein 2


chr12_-_36769054 9.621 NM_025359
Tspan13
tetraspanin 13
chr11_+_54117703 9.544 NM_001033597
NM_144823
Acsl6

acyl-CoA synthetase long-chain family member 6

chr7_+_31092787 9.480 Clip3
CAP-GLY domain containing linker protein 3
chr2_-_113669229 9.271 Scg5
secretogranin V
chr11_+_87032504 9.042 Trim37
tripartite motif-containing 37
chr7_-_31935974 8.865 NM_027898
Gramd1a
GRAM domain containing 1A
chr11_-_41996141 8.687 NM_010250
Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr15_+_89284625 8.567 Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
chr6_+_114232618 8.535 NM_178703
Slc6a1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr2_+_177876710 8.475 Phactr3
phosphatase and actin regulator 3
chr9_-_75459046 8.452 Tmod2
tropomodulin 2
chr2_+_164793698 8.336 Slc12a5
solute carrier family 12, member 5
chr12_+_89961317 8.110 NM_001198587
Nrxn3
neurexin III
chr2_-_26883441 8.014 NM_001177627
NM_172659
Slc2a6

solute carrier family 2 (facilitated glucose transporter), member 6

chr15_+_89284631 7.873 Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
chr6_+_110595586 7.596 NM_177328
Grm7
glutamate receptor, metabotropic 7
chrX_-_161765324 7.051 Glra2
glycine receptor, alpha 2 subunit
chr13_+_88961034 7.002 NM_001037987
NM_010103
Edil3

EGF-like repeats and discoidin I-like domains 3

chr2_+_177876858 6.995 Phactr3
phosphatase and actin regulator 3
chr11_-_114862859 6.872 AF251705
cDNA sequence AF251705
chr13_+_54472705 6.618 NM_009946
Cplx2
complexin 2
chr1_-_195196423 6.571 NM_144817
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr4_-_126430511 6.528 NM_011986
Ncdn
neurochondrin
chr5_+_150076605 6.469 NM_009663
Alox5ap
arachidonate 5-lipoxygenase activating protein
chr6_+_51494591 6.371 Snx10
sorting nexin 10
chr7_+_108570222 6.342 Pde2a
phosphodiesterase 2A, cGMP-stimulated
chr4_-_141430740 6.244 NM_025994
Efhd2
EF hand domain containing 2
chr14_-_66832383 6.199 NM_001162366
Ptk2b
PTK2 protein tyrosine kinase 2 beta
chr9_-_75458954 6.070 Tmod2
tropomodulin 2
chr4_+_132530088 6.007 Fgr
Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
chr7_+_134439804 5.945 NM_008400
Itgal
integrin alpha L
chr9_-_75458918 5.939 Tmod2
tropomodulin 2
chr9_-_53823107 5.930 NM_177769
Elmod1
ELMO domain containing 1
chr11_+_54117299 5.904 NM_001033598
Acsl6
acyl-CoA synthetase long-chain family member 6
chr6_-_113451811 5.856 NM_172487
Prrt3
proline-rich transmembrane protein 3
chr6_-_113451922 5.839 Prrt3
proline-rich transmembrane protein 3
chr6_+_114232767 5.639 Slc6a1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr2_+_49474840 5.578 Kif5c
kinesin family member 5C
chr6_+_137359231 5.464 NM_001164402
NM_001164403
Ptpro

protein tyrosine phosphatase, receptor type, O

chr2_-_181049204 5.407 NM_009133
Stmn3
stathmin-like 3
chr10_+_72119562 5.384 Zwint
ZW10 interactor
chr7_-_51787440 5.363 NM_019866
Spib
Spi-B transcription factor (Spi-1/PU.1 related)
chr11_+_87607285 5.351 NM_010824
Mpo
myeloperoxidase
chr1_+_133558486 5.129 Ctse
cathepsin E
chr11_+_87607531 5.056 Mpo
myeloperoxidase
chr17_-_57184507 5.030 Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr1_+_133558507 5.028 Ctse
cathepsin E
chr2_-_113669243 4.942 NM_009162
Scg5
secretogranin V
chr5_-_141476549 4.926 NM_175362
Card11
caspase recruitment domain family, member 11
chr7_+_17460662 4.895 NM_001081655
Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)
chr5_-_103640272 4.883 NM_001081567
NM_009158
Mapk10

mitogen-activated protein kinase 10

chr9_-_75459125 4.857 NM_016711
Tmod2
tropomodulin 2
chr1_+_133558517 4.836 Ctse
cathepsin E
chr17_-_23908488 4.816 NM_153791
Flywch1
FLYWCH-type zinc finger 1
chr6_-_58857000 4.792 NM_021432
Nap1l5
nucleosome assembly protein 1-like 5
chr4_+_132530104 4.764 Fgr
Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
chr2_+_38194775 4.725 Lhx2
LIM homeobox protein 2
chr18_+_77424573 4.672 NM_013666
NM_153124
St8sia5

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

chr3_+_87975676 4.620


chr2_-_113669159 4.618 Scg5
secretogranin V
chr15_+_89284554 4.576 Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
chr1_+_165992203 4.543 NM_001164059
NM_011346
Sell

selectin, lymphocyte

chr7_+_134439888 4.540 Itgal
integrin alpha L
chr7_+_150191542 4.387 NM_001128081
NM_001128082
NM_020286
Tspan32


tetraspanin 32


chr4_+_41836783 4.370 NM_001085530
Gm13298
predicted gene 13298
chr17_+_56092075 4.340 Ebi3
Epstein-Barr virus induced gene 3
chr7_+_4085699 4.273 Ttyh1
tweety homolog 1 (Drosophila)
chr18_-_78320126 4.234 NM_001171010
NM_028122
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr17_+_56092045 4.137 NM_015766
Ebi3
Epstein-Barr virus induced gene 3
chr10_-_7357774 4.134 Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr5_+_117583596 4.058 NM_001081308
Taok3
TAO kinase 3
chr7_-_31699850 4.055 NM_010758
Mag
myelin-associated glycoprotein
chr2_+_121134843 4.038 Mtap1a
microtubule-associated protein 1 A
chr10_-_88145766 4.011 NM_011461
Spic
Spi-C transcription factor (Spi-1/PU.1 related)
chr4_-_43467398 3.992 NM_001110320
NM_001110321
NM_001110322
NM_007654
Cd72



CD72 antigen



chr18_-_55149819 3.921 NM_175751
Zfp608
zinc finger protein 608
chrX_-_61530170 3.808 NM_178740
Slitrk4
SLIT and NTRK-like family, member 4
chrX_+_38754605 3.802 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr15_-_27955680 3.779 Trio
triple functional domain (PTPRF interacting)
chrX_-_69901382 3.777 NM_008067
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr8_-_88364846 3.697 NM_028007
Itfg1
integrin alpha FG-GAP repeat containing 1
chr11_-_41995688 3.686 Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr11_-_99016390 3.685 NM_007719
Ccr7
chemokine (C-C motif) receptor 7
chr7_+_52956589 3.615 Car11
carbonic anhydrase 11
chr16_-_95078278 3.593 NM_001025590
Kcnj6
potassium inwardly-rectifying channel, subfamily J, member 6
chr11_+_106612525 3.586 NM_001033435
Gm885
predicted gene 885
chr2_-_153051118 3.563 NM_198617
Tspyl3
TSPY-like 3
chr17_+_48403658 3.476 NM_001033922
NM_001163795
NM_001163796
NM_172623
Treml4



triggering receptor expressed on myeloid cells-like 4



chr8_+_115093942 3.442 NM_130457
Cntnap4
contactin associated protein-like 4
chr2_+_158492854 3.418 NM_001159662
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr5_+_141200067 3.406 NM_173405
Amz1
archaelysin family metallopeptidase 1
chr7_+_26412621 3.394 NM_001036740
NM_146184
B3gnt8

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

chr3_-_123375305 3.358 NM_031186
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chrX_+_38754480 3.350 NM_016886
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr11_+_3352465 3.332 8430429K09Rik
RIKEN cDNA 8430429K09 gene
chr6_-_134837738 3.312 NM_001167697
NM_001167699
NM_008157
Gpr19


G protein-coupled receptor 19


chrX_+_38754568 3.305 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chrX_-_141122722 3.286 NM_009428
Trpc5
transient receptor potential cation channel, subfamily C, member 5
chr13_+_58909254 3.285 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr13_+_88961161 3.273 Edil3
EGF-like repeats and discoidin I-like domains 3
chr7_-_116226796 3.269 NM_001038624
NM_178780
Ric3

resistance to inhibitors of cholinesterase 3 homolog (C. elegans)

chr15_-_84277488 3.237 NM_001163145
1810041L15Rik
RIKEN cDNA 1810041L15 gene
chr2_+_164793487 3.237 NM_020333
Slc12a5
solute carrier family 12, member 5
chr6_-_18464792 3.220 NM_080285
Cttnbp2
cortactin binding protein 2
chr2_+_28496752 3.177 NM_022887
Tsc1
tuberous sclerosis 1
chr6_+_86388364 3.165 NM_146170
C87436
expressed sequence C87436
chr5_-_118694869 3.146 NM_172998
NM_001109902
Rnft2

ring finger protein, transmembrane 2

chr15_+_82105322 3.098 NM_011889
Sept3
septin 3
chr17_+_7374435 3.063 NM_011299
Rps6ka2
ribosomal protein S6 kinase, polypeptide 2
chr15_+_89284449 3.062 Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
chr8_+_26707480 3.052 D830025C05Rik
RIKEN cDNA D830025C05 gene
chr10_-_61738537 3.026 Hk1
hexokinase 1
chr10_+_98453513 2.996 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr7_-_28327749 2.990 Pld3
phospholipase D family, member 3
chrX_+_71002395 2.977 NM_019587
Plxnb3
plexin B3
chr2_-_181048957 2.970 Stmn3
stathmin-like 3
chr11_-_119908236 2.941 NM_001198785
NM_007377
Aatk

apoptosis-associated tyrosine kinase

chr5_+_107832528 2.934 NM_001001804
Ephx4
epoxide hydrolase 4
chr5_-_141476424 2.912 Card11
caspase recruitment domain family, member 11
chr5_+_138011078 2.866 NM_015799
Trfr2
transferrin receptor 2
chr7_+_72789752 2.852 NM_172310
Tarsl2
threonyl-tRNA synthetase-like 2
chr17_+_57498108 2.837 NM_010130
Emr1
EGF-like module containing, mucin-like, hormone receptor-like sequence 1
chr7_+_5008311 2.824 NM_146178
Ccdc106
coiled-coil domain containing 106
chr18_-_16967100 2.759 Cdh2
cadherin 2
chr2_+_125073450 2.755 Dut
deoxyuridine triphosphatase
chr5_+_135499346 2.741 NM_016801
Stx1a
syntaxin 1A (brain)
chr4_-_133927533 2.721 Extl1
exostoses (multiple)-like 1
chr18_-_16967557 2.720 NM_007664
Cdh2
cadherin 2
chr2_+_164793796 2.684 Slc12a5
solute carrier family 12, member 5
chrX_-_47150892 2.673 NM_177591
NM_177915
Igsf1

immunoglobulin superfamily, member 1

chr7_+_52419289 2.665 NM_182993
Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr7_+_52419317 2.593 Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr17_+_57244807 2.582 NM_009404
Tnfsf9
tumor necrosis factor (ligand) superfamily, member 9
chr2_+_49474775 2.567 NM_008449
Kif5c
kinesin family member 5C
chr11_+_121098532 2.566 NM_026272
Narf
nuclear prelamin A recognition factor
chrX_+_4446526 2.565 NM_001099643
Gm3750
predicted gene 3750
chr18_-_78320014 2.542 Slc14a1
solute carrier family 14 (urea transporter), member 1
chr18_-_16967754 2.520 Cdh2
cadherin 2
chr5_+_111032523 2.518 NM_001122639
Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chrX_+_38754658 2.459 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr8_-_88364760 2.440 Itfg1
integrin alpha FG-GAP repeat containing 1
chr2_-_129134865 2.424 Il1a
interleukin 1 alpha
chr7_-_134164627 2.421 NM_001102563
Prrt2
proline-rich transmembrane protein 2
chr3_+_96400524 2.417 NM_001024851
Ankrd34a
ankyrin repeat domain 34A
chr6_+_51494521 2.414 NM_001127348
NM_028035
Snx10

sorting nexin 10

chr8_+_14777772 2.413 Dlgap2
discs, large (Drosophila) homolog-associated protein 2
chr13_-_14155541 2.411 Ggps1
geranylgeranyl diphosphate synthase 1
chr14_+_55555300 2.410 NM_026066
Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr15_+_99501148 2.398 NM_009597
Accn2
amiloride-sensitive cation channel 2, neuronal
chrX_-_131745187 2.395 NM_025355
Tceal6
transcription elongation factor A (SII)-like 6
chr3_+_105508375 2.393 NM_001163356
6530418L21Rik
RIKEN cDNA 6530418L21 gene
chr15_+_78744328 2.393 NM_020271
Pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chrX_-_61530035 2.379 Slitrk4
SLIT and NTRK-like family, member 4
chrX_+_3748193 2.379 NM_001099643
Gm3750
predicted gene 3750
chr14_-_55735114 2.365 NM_177049
Jph4
junctophilin 4
chr11_-_79343891 2.359 Evi2a
ecotropic viral integration site 2a
chr18_+_40418014 2.355 NM_026135
Kctd16
potassium channel tetramerisation domain containing 16
chr4_-_141567551 2.327 NM_177868
Fhad1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr4_-_140616455 2.316 NM_001145958
Crocc
ciliary rootlet coiled-coil, rootletin
chr19_-_11698132 2.296 NM_013516
Ms4a2
membrane-spanning 4-domains, subfamily A, member 2
chr2_+_92755251 2.295 NM_030725
Syt13
synaptotagmin XIII
chr12_+_71008808 2.176 Atl1
atlastin GTPase 1
chr11_-_79344055 2.155 NM_001033711
NM_010161
NM_146023
Evi2a

Evi2b
ecotropic viral integration site 2a

ecotropic viral integration site 2b
chr7_+_50692442 2.155 NM_024253
Nkg7
natural killer cell group 7 sequence
chr1_-_173537404 2.104 NM_008534
Ly9
lymphocyte antigen 9
chr8_-_73982014 2.096 Abhd8
abhydrolase domain containing 8
chr7_-_52467149 2.094 Dkkl1
dickkopf-like 1
chr5_-_143084748 2.084 Mmd2
monocyte to macrophage differentiation-associated 2
chr4_+_88473179 2.063 NM_206871
Ifna6
interferon alpha 6
chr17_+_37210011 2.022 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr8_+_72426082 2.017 NM_032004
Tssk6
testis-specific serine kinase 6
chr14_-_33998251 2.009 NM_001146022
Wdfy4
WD repeat and FYVE domain containing 4
chr6_-_122806122 2.005 NM_009779
C3ar1
complement component 3a receptor 1
chr6_+_124946723 1.985 NM_175696
C530028O21Rik
RIKEN cDNA C530028O21 gene
chr19_-_37250472 1.984 Cpeb3
cytoplasmic polyadenylation element binding protein 3
chr14_-_64606614 1.977 NM_026359
4930578I06Rik
RIKEN cDNA 4930578I06 gene
chr6_+_57652448 1.950 NM_133737
Lancl2
LanC (bacterial lantibiotic synthetase component C)-like 2
chr3_-_88964115 1.939 Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chrX_-_30292985 1.928 NM_001085545
NM_001085551
NM_001085552
NM_001085553
Gm2933
Gm14345
Gm14346
Gm14351
Gm10921
Gmcl1l
predicted gene 2933
predicted gene 14345
predicted gene 14346
predicted gene 14351
predicted gene 10921
germ cell-less homolog 1 (Drosophila)-like
chr7_+_108570211 1.920 NM_001008548
NM_001143848
Pde2a

phosphodiesterase 2A, cGMP-stimulated

chr13_-_31065909 1.917 NM_025588
Exoc2
exocyst complex component 2
chr11_-_34597324 1.905 NM_033374
Dock2
dedicator of cyto-kinesis 2
chr2_-_3339919 1.863 NM_008579
Meig1
meiosis expressed gene 1
chr7_+_133924996 1.831 NM_011538
Tbx6
T-box 6

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.09 7.51e-03 GO:0043005 neuron projection
1.74 8.61e-03 GO:0042995 cell projection
2.09 2.57e-02 GO:0045202 synapse
3.67 2.68e-02 GO:0019898 extrinsic to membrane

Nothing significant found in function category.